Anti-nociceptive and antiinflammatory effects of the hydroalcoholic extract of the Spergularia Marina (L). Griseb in male mice

Authors : Kaveh TABRİZİAN, Abdolhossein MİRİ, Elahe SHAHRAKİ, Soheil OUDİ

Pages : 1733-1738

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Publication Date : 2015-05-13

Article Type : Review Paper

Abstract :Abstract. In this study, the anti-nociceptive properties of hydroalcoholic extract of Spergularia Marina (L). Griseb in male mice were carried out using chemical (writhing and formalin) and thermal (hot plate) models of nociception. Cotton pellet- induced granuloma model was used for anti- inflammatory investigations in male mice. Spergularia Marina hydroalcoholic extract (12.5, 25 and 50 mg/kg, oral gavage) reduced time and number of paw licks during the second phase of the formalin test and the number of writhings. This extract did not show any significant analgesia on acute pain in first phase of the formalin test. Also, the effect of the extract (25 and 50 mg/kg, p.o.) in sciatic nerve ligation model provides a confirmation of its probable antineuropathic pain properties. Anti-inflammatory effect of this extract (50 mg/kg) was confirmed by a significant decrease in Cotton pellet weight in male mice.
Keywords : Antinociception, Spergularia Marina, Sciatic Nerve ligation, Formalin test, Inflammation

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