Diastereomeric Separation of a Novel Chalcone Derivative by Chiral HPLC

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Adıyaman Üniversitesi Fen Bilimleri Dergisi
Volume:11 Issue:1
Diastereomeric Separation of a Novel Chalcone Derivative by Chiral HPLC

Diastereomeric Separation of a Novel Chalcone Derivative by Chiral HPLC

Pages : 205-214

View : 30 | Download : 26

Publication Date : 2021-06-30

Article Type : Research Paper

Abstract :In this study, a facile and versatile procedure for the synthesis of a chalcone derivate that a functionalized (E,Z)-2-(4-aminobenzylidene)acenaphthylen-1(2H)-one, 4 was synthesized and also characterized by using FT-IR, NMR and MS. A new HPLC method for the separation of its diastereomers was developed by using a chiral column that contains the amylose tris(3,5-dimethylphenylcarbamate) as a chiral selector since it is effective, reproducible and can be used for preparative purposes. High percentage recovery claims that the presented method was not affected by the impurities in the biological media. RSD% values for the repeatability studies suggest that the optimized method was highly precise and reproducible which is very important for these promising advances, chalcone-based science is expected to be applied in drug discovery.
Keywords : Chalcone, Diastereomeric separation, Acenaphtenone, Chiral column, HPLC

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