Incidental findings of brain magnetic resonance imaging in patients with treatment-resistant depression

Authors : Olga Bayar Kapıcı, Yaşar Kapıcı, Mehmet Şirik, Dilek Örüm

Pages : 27-36

Doi:10.30569/adiyamansaglik.1573897

View : 101 | Download : 74

Publication Date : 2025-04-23

Article Type : Research Paper

Abstract :Aim: In this study, incidental findings of brain magnetic resonance imaging (MRI) of patients diagnosed with treatment-resistant depression (TRD) were compared with healthy controls (HC). Materials and Methods: The study included 68 patients with TRD (42 females, 26 males) and 72 HC (35 females, 37 males). Global assessment scale (GAS) was administered. Results: In the TRD group, those with general cerebral atrophy were found to have significantly lower global assessment scale (GAS) scores (p<0.001). In the TRD group, those with cavum veli interpositi (CVI) were found to have significantly lower GAS scores (p=0.001). In the TRD group, when the effect of age was controlled, a significant correlation was found between the GAS score and the duration of the disorder (r=-0.400; p=0.001). Conclusion: CVI, a neurodevelopmental abnormality, has been shown to be more common in patients diagnosed with TRD.
Keywords : Tedaviye dirençli majör depresif bozukluk, Manyetik rezonans görüntüleme, Tesadüfi bulgu

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