INH Direnç Mekanizmaları
Authors : Tanseli GÖNLÜGÜR, Ugur GÖNLÜGÜR
Pages : 287-292
Doi:10.5798/dicletip.339020
View : 22 | Download : 11
Publication Date : 2017-09-20
Article Type : Review Paper
Abstract :Normal 0 21 false false false TR X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Normal Tablo"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} H e r n e ka d a r izo n i a zid ( I N H) ‘ ın M y c o b ac t e r ium t u b er c u l osis ü z er i n d e k i e t k i m e ka n i zm as ı t a m a n laş ı la m a mış o l s a da ö n c ü i la ç o la n I N H s it o p la zm a ya p as if d i füzyon i l e g i r m e k t e di r . KatG g en i t a r a f ı n d a n k od la n a n ka t ala z / p e r o ks id a z en z i mi i l e ak ti f le n m e k t e di r . I N H ‘ ı n ak ti f l en m e s i i l e s e r be s t m e t a b o l ik r a di kall e r o l u ş m ak t a , b un la r da mi k o l ik as it s en t e zi g i b i p e k ç ok h ücr e s e l f o n ks iyo n u b o z m ak t a dı r la r . KatG mut as yonl a r ı I N H di r en c i n in a n a seb eb i di r . I N H ' a di r en çl i kl i n ik izo la t la r ın % 50 ' d e n f a z l as ı n da ka tG 31 5 . pozisyo n da s e r in y e r i n e t r e o n in ' i n d e ğişti ğ i b i r m u t as yon v a r dı r . İnhA, n dh v e po m pa g e n le r i gi b i g e n l e r d e I N H d i r en c i n e ka t k ıda b u l un a b i l i r le r . Bu d er l e m e y a zı s ı M y c o b ac t er i u m t u b er c u l osis ' de I N H e t k i m e ka n izm as ı n ı ve i la ç di re n c i n i n m o l e k ü l e r t e m e ll er i n i öz e t l e m e k t e d i r .Keywords : İzoniazid, direnç, mekanizma, tüberküloz