Investigation of serum oxidative stress levels in patients with nasal polyps

Authors : Adnan Ekinci

Pages : 1-7

Doi:10.5798/dicletip.407237

View : 20 | Download : 13

Publication Date : 2018-03-10

Article Type : Research Paper

Abstract :Objective:  To  compare  serum  total  antioxidant  status  (TAS),  total  oxidant  status  (TOS),  and  paraoxonase  (PON1) levels between nasal polyp patients and heal thy subjects. Method: In the present study, The nasal polyp group includes 26 males an 22 females, a total of 48 patients (mean age 37.11±12.07 years), while the control group included 22 males and 24 females, a total of 46 healthy subjects (mean age 36.91±13.03) years. Groups were compared in terms of serum TAS, TOS and PON1 levels. Results:  The  mean  TAS  level  was  1.248  mmol/L  in  the  control  group,  it  was  1.176  mmol/L  in  the  patient  group (p=0.044). The mean TOS level was 3.443 mmol/L in the control group, and it was 6.720 mmol/L in the patient group (p=006).  Nasal  polyp  and  control  groups  did  not  show  any  significant  difference  for  PON1  (301.15  U/L  vs.  295.75 U/L,p>0.05).  Conclusion: Serum TOS levels were significantly higher, and TAS levels were significantly lower in patients with nasal polyposis  compared  it  the  control  group.  There  was  no  significant  difference  between  the  patients  with  nasal polypand the control group in terms of the PON1 values.
Keywords : Nasal Polyp, Total Oxidant Status, Total Antioxidant Status