Prognostic Value of Lymph Node and Spleen Activity in [18F]FDG PET-CT in Lung Adenocarcinoma and Squamous Cell Carcinoma

Authors : Halil KOMEK, Nadiye AKDENİZ, Zuhat URAKCİ, Canan CAN, Serdar ALTİNDAG

Pages : 1-10

Doi:10.5798/dicletip.534806

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Publication Date : 2019-03-03

Article Type : Research Paper

Abstract :Objective: We aimed to investigate the prognostic value of primary mass, spleen and lymph node metabolic activity in [18F]FDG PET-CT as well as the prognostic value of neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (TLR) in patients with lung adenocarcinoma and squamous cell carcinoma. Objective: We aimed to investigate the prognostic value of primary mass, spleen and lymph node metabolic activity in [18F]FDG PET-CT as well as the prognostic value of neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (TLR) in patients with lung adenocarcinoma and squamous cell carcinoma. Results:  The  SUVmax  spleen/liver  and  SUVmax  lymph  node/liver  ratios  were  significantly  higher  in  the  exitus subgroup  of  squamous  cell  carcinoma  (p=0.025,  p=0.043;  respectively).  The  SUVmax  lymph  node/liver  ratio  was found to be a  predictor for  survival in squamous cell carcinoma (p=0.019, OR:1.282). The SUVmax spleen/liver and SUVmax lymph node/liver ratios were similar between subgroups of adenocancer.  Conclusions:  The  SUV  ratios  of  the  spleen  were  not  a  predictor  for  survival  in  both  groups.  The  SUVmax  lymph node/liver ratio was found to be a predictor for survival in squamous cell carcinoma. However, NLR and PLR were not found to be prognostic factors. 
Keywords : Lung cancer, spleen activity, survival, 18F, FDG PET CT