Apelin-13 and Epilepsy

Authors : Fatma Banu Ayçik, Erdal Agar

Pages : 82-88

View : 46 | Download : 54

Publication Date : 2023-12-31

Article Type : Research Paper

Abstract :Apelin, a neuropeptide, is a typical endogenous ligand of G protein-coupled apelin receptor, APJ. Apelin mRNAs, proteins and APJ are commonly found in peripheral tissues and the central nervous system (CNS). Thus apelin-APJ system may be related to many physiological and pathological processes such as epilepsy. Epilepsy is severe chronic neurological disease and affects millions of people worldwide. Disruption of the balance between excitation and inhibition can cause epilepsy. There are few studies about apelin and epilepsy interactions. Clarifying the effect of apelin on epilepsy will be important for the development of treatment.
Keywords : Apelin 13, APJ, Neuroproteksiyon, Epilepsi