Investigation of the Anti-cancer, Antioxidant, and Anti-microbial Potential of Cold-Pressed Ficus carica L. cv. Yellow Lop Seed Oil

Authors : Adem Yavaş

Pages : 279-286

Doi:10.25308/aduziraat.1778466

View : 48 | Download : 41

Publication Date : 2025-12-31

Article Type : Research Paper

Abstract :This study evaluates the bioactive properties of cold-pressed seed oil from the Turkish Sarı Lop fig (Ficus carica L. cv.), focusing on its anti-cancer, antioxidant, and antimicrobial potential for nutraceutical and pharmaceutical applications. The oil\\\'s phytochemical profile, including its fatty acid composition, tocopherol content, and total phenolic content, was characterized using chromatographic and spectrophotometric methods. Its biological activities were assessed via the DPPH radical scavenging assay, Minimum Inhibitory Concentration (MIC) determination against pathogenic bacteria (Staphylococcus aureus and Escherichia coli) and MTT cytotoxicity assays on human breast (MCF-7) and prostate (PC-3) cancer cell lines. Analysis revealed the oil is a rich source of unsaturated fatty acids, dominated by linolenic acid (42.1%), linoleic acid (31.5%), and oleic acid (14.8%). It also contains high concentrations of γ-tocopherol (395 mg/100 g) and significant phenolic compounds (45.8 mg GAE/g). The oil demonstrated potent antioxidant activity (IC50=5.62 mg/mL) and broad-spectrum antimicrobial efficacy, with MIC values ranging from 0.5 to 2 mg/mL. Furthermore, it exhibited dose-dependent cytotoxic effects against both tested cancer cell lines, showing the highest selectivity towards MCF-7 breast cancer cells. These findings establish Sarı Lop fig seed oil as a valuable natural resource with significant therapeutic potential, making it a promising candidate for the development of novel functional foods, nutraceuticals, and innovative therapeutic agents.
Keywords : Anti-kanser, Antioksidan, Anti-mikrobiyal, Ficus carica, İncir çekirdeği yağı

ORIGINAL ARTICLE URL