Effect of Different MMP Inhibitors on the Bond Strength and Durability of an Etch-and-rinse and a Self-etch Adhesive

Authors : Ahmet Hazar, Mine Betül Üçtaşlı
Pages : 453-460
Doi:10.54617/adoklinikbilimler.1485108
View : 67 | Download : 85
Publication Date : 2024-09-24
Article Type : Research Paper
Abstract :Aim: To compare the effect of different matrix metalloproteinase (MMP) inhibitors on the microtensile bond strength (μTBS) of an etch-and-rinse adhesive and a self-etch adhesive at baseline and after aging. Materials and Method: Flat dentin surfaces were prepared from 96 extracted, sound human molars. Teeth were randomly divided into two main groups according to the adhesives (Adper Single Bond 2, and Clearfil 3S Plus) used (n=48). Each group was divided into four subgroups according to the dentin surface treatments; untreated (control), pretreated with 2% chlorhexidine digluconate (CHX) before adhesive application, pretreated with 1% benzalkonium chloride (BAC) before adhesive application, and pretreated with 2% hesperidin (HPN) before adhesive application (n=12). Composite resin was then placed on the prepared surfaces and polymerized. The specimens were cut to obtain dentin beams and randomly divided into two groups for microtensile analysis at baseline and after 6 months of aging. Failure types were observed test after microtensile tests and data were analyzed by Two-way ANOVA, Tukey HSD, and Chi-Square tests (p <0.05). Results: Compared with control, all MMP inhibitors significantly preserved and improved the bond strength of both adhesives at baseline and after 6 months of aging (p < 0.05). When considering the comparison of MMP inhibitors, bond strengths of both adhesives in the HPN and BAC groups were significantly higher than CHX group after aging (p < 0.05). The failure types were mostly adhesive and mixed. Conclusion: The use of 2% HPN and 1% BAC as a separate step before the adhesive application can be recommended to preserve the longevity of resin-dentin bond strength on etch-and-rinse and self-etch adhesives.
Keywords : Adezivler, Benzalkonyum klorür, klorheksidin diglukonat, hesperidin

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