Therapeutic Plasma Exchange in Adult Patients with COVID-19 and Severe Pneumonia: Single Center Experience of Eighty Patients

Authors : Bilal AYGUN, Funda PEPEDİL TANRİKULU, Mahmut Bakır KOYUNCU

Pages : 15-20

Doi:10.18678/dtfd.1179587

View : 20 | Download : 16

Publication Date : 2023-04-30

Article Type : Research Paper

Abstract :Aim: Therapeutic plasma exchange insert ignore into journalissuearticles values(TPE); is a frequently discussed treatment modality in severe coronavirus disease 2019 insert ignore into journalissuearticles values(COVID-19); patients. It requires an apheresis device and experienced personnel for the application. In this study, we aimed to reveal the characteristics and clinical outcomes of adult patients with COVID-19 who experienced TPE. Material and Methods: Adult patients who had undergone TPE in our apheresis unit were retrospectively analyzed and COVID-19-positive cases were included in the study. All the medical information about the cases was obtained from the electronic database and technical details of the procedures were gathered from apheresis unit records. Results: A total of 80 patients with a median age of 60 insert ignore into journalissuearticles values(19-85); years were included in the study. Severe pneumonia was present in 98.8% insert ignore into journalissuearticles values(n=79); of the cases. More than three-quarters of the patients had lymphopenia, critically elevated C-reactive protein insert ignore into journalissuearticles values(CRP);, and D-dimer, and 41.0% insert ignore into journalissuearticles values(n=32); had high ferritin. The median length of stay in the intensive care unit was 26 insert ignore into journalissuearticles values(5-124); days. The mortality rate observed on the 14th and 28th days following the TPE procedure was 51.3% insert ignore into journalissuearticles values(n=41); and 75.0% insert ignore into journalissuearticles values(n=60);, respectively. High ferritin level, multiple organ failure insert ignore into journalissuearticles values(MOF);, and intubation were parameters found to be associated with mortality in the multivariate analysis. Conclusion: The mortality rate observed in patients with COVID-19 who underwent TPE in our study was similar to the cases in the literature without the procedure, while it has been shown that high ferritin levels, intubation, and the presence of MOF increase the risk of mortality.
Keywords : terapötik plazma değişimi, pnömoni, COVID 19