Rapid Deswelling of PDMAEMA Hydrogel in Response to pH and Temperature Changes and Its Application in Controlled Drug Delivery

Authors : Fulya TAKTAK

Pages : 68-75

Doi:10.5578/fmbd.26306

View : 30 | Download : 13

Publication Date : 2015-04-30

Article Type : Research Paper

Abstract :In this study, poly(2‐dimethylamino)ethyl methacrylate (PDMAEMA)    gels were prepared via in situ polymerization reaction. Synthesized hydrogel was characterized with FTIR spectroscopy and SEM. The pH‐ and temperature dependentswelling / deswelling behavior was investigated. The hydrogelshowed highest value of swelling at pH 2. The rising temperature led to a decrease in swelling ratio due to the fact that hydrophobic interactions between polymer segments become dominant. Furthermore, it was observed that PDMAEMA hydrogel exhibited rapid deswelling rate in response to temperature and pH. The drug release profile of PDMAEMA hydrogel has been reported by using Ibuprofen as a model drug.
Keywords : Hydrogel, Controlled drug delivery, Rapid response, Deswelling