The Composite Microbeads of Alginate, Carrageenan, Gelatin, and Poly-(Lactic-co-Glycolic Acid): Swelling, Cefaclor Loading and Release

Authors : Buse Semerci Arıkan, Demet Baybaş

Pages : 738-756

Doi:10.35414/akufemubid.1560061

View : 63 | Download : 90

Publication Date : 2025-08-04

Article Type : Research Paper

Abstract :Composite microbeads were synthesized as a combination of two, three, or four of the following components: alginate(A), carrageenan(C), gelatin(G), and/or poly (lactic-co-glycolic acid)(P). Herein, Cefaclor(Cef) was investigated as a model drug to study the usability of the beads in drug delivery. The composite microspheres with medication and drug-free were synthesized under different conditions. Fourier Transform Infrared (FTIR) spectra of these composites were compared. The effects of synthesis conditions such as component amounts, cross-linker ion amounts on swelling, entrapment efficiency, and release kinetics of materials were examined. The maximum swelling comparison of the hydrogel composites is A(981%)>AP(747%)>ACGP(641%)>ACG(618%)>ACP(464%)>AC(442%)>AGP(295%)>AG(157%). Adding PLGA to the alginate sphere reduces the swelling contrast adding PLGA to the composite beads containing other components increases the swelling %. As the amount of PLGA added to the ACP spheres increases, the swelling decreases. The maximum entrapment efficiency of cefaclor in micro-composites is ACP(93%)>AC(76%)>AP(66%)>ACG=AGP(46%)>AG(40%)>ACGP(39%)>A(36%). All release experiments were carried out in simulated gastric fluid without enzyme at body temperature, with new solutions in a shaking medium. The release of cefaclor from the composite beads did not generally show a burst effect. The selected data fit the first-order release kinetics and the Korsmeyer Peppas and Higuchi drug release models.
Keywords : sefaklor salınımı, , aljinat, , karragenan, , jelatin, , poli(laktik-ko-glikolik asit)

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