Protective Effects of L-carnitine and Co-enzyme Q10 Against Oxidative Stress Damage in Hypertension

Authors : Tarık MECİT, Nadide NABIL KAMILOĞLU, Pelin ŞAHIN, Dinçer ERDAĞ, Oğuz MERHAN

Pages : 30-37

Doi:10.32707/ercivet.1259252

View : 25 | Download : 10

Publication Date : 2023-04-03

Article Type : Research Paper

Abstract :In this study, it was aimed to investigate the effects of L-carnitine and Co-enzyme Q10 administration together with ACE Inhibitor insert ignore into journalissuearticles values(ACE inh.); on oxidative stress parameters in liver, brain and kidney tissues in L-NAME hypertensive rats. At the study, divided all rats into eight groups, four groups with 14 days of experiment time and four groups with 28 days of experiment time. At the end of the experiment, the rats were euthanized and their liver, brain and kidney tissues were taken. Malondialdehyde insert ignore into journalissuearticles values(MDA);, glutathione insert ignore into journalissuearticles values(GSH); and nitric oxide insert ignore into journalissuearticles values(NO); activities were measured in tissue supernatants. While NO and MDA levels increased in all tissues, a significant decrease was observed in GSH levels insert ignore into journalissuearticles values(P<0.001);. In conclusion, it is suggested that supplementation of L-carnitine and CoQ10 can be considered as a combination therapy strategy for patients prone to higher levels of oxidative stress and inflammation.
Keywords : ACE inhibitörü, hipertansif, koenzim Q10, L karnitin