Biological Activities of Two Stacys Species: Stachys thirkei K. Koch and Stachys macrantha (K. Kock) Stearn

Authors : Gökçe Yıldırım Buharalıoğlu, Recep İlhan, Hasan Yıldırım, Ceren Emir

Pages : 789-798

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Publication Date : 2025-12-31

Article Type : Research Paper

Abstract :The study aimed to investigate the antioxidant activities of methanol extracts from Stachys thirkei and Stachys macrantha growing in Eastern Anatolia using the DPPH and ABTS methods, as well as their cytotoxic effects on BPH, DU-145, PC-3, and LNCaP cell lines by MTT assay. Radical scavenging activities were determined spectrophotometrically, revealing that both species exhibited high antioxidant capacity; however, S. thirkei demonstrated relatively higher activity. In the preliminary investigation of potential treatments for prostate cancer, neither species affected the viability of the BPH, DU-145, or PC-3 cell lines. Only the S. thirkei extract exhibited a cytotoxic effect on LNCaP cell lines, with an IC50 value of 19.25 µg/mL.
Keywords : Stachys thirkei, Stachys macrantha, antioksidan aktivite, sitotoksisite

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