INVESTIGATION OF SIMULTANEOUS ADMINISTRATION OF PPR (PESTE DES PETITS RUMINANTS) AND BLUETONGUE VACCINES IN MERINO SHEEP

Authors : Züleyha ERGÜN

Pages : 16-22

Doi:10.35864/evmd.1272630

View : 42 | Download : 45

Publication Date : 2023-06-20

Article Type : Research Paper

Abstract :Abstract: Peste des Petits Ruminants insert ignore into journalissuearticles values(PPR); and Bluetongue insert ignore into journalissuearticles values(BT);, which are among the contagious animal diseases, cause serious economic losses and are included in the notifiable diseases by the World Organization for Animal Health insert ignore into journalissuearticles values(WOAH);. PPR and BT vaccines are widely used in countries where outbreaks occur. In this study, we aimed to examine the neutralizing antibody response of simultaneously administered PPR and BT serotype 4 vaccines in sheep. For this purpose, a study was performed under field conditions in a state-owned breeding farm. All the experimental animals were confirmed seronegative by serum neutralization test insert ignore into journalissuearticles values(SNT); for antibodies to the PPR virus insert ignore into journalissuearticles values(PPRV); and BT virus serotype 4 insert ignore into journalissuearticles values(BTV4);. Subsequently, the experimental animals were divided into four groups. Group 1 insert ignore into journalissuearticles values(Group 1/PPR; lamb n=10, sheep n=10); and group 2 insert ignore into journalissuearticles values(Group 2/BTV4; lamb n=10, sheep n=10); were vaccinated separately with the PPR and BTV4 vaccines. Group 3 was vaccinated simultaneously with PPR and BTV4 insert ignore into journalissuearticles values(Group 3/PPR-BTV4; lamb n=10, sheep n=10);. Group 4 was unvaccinated and served as the control. In each of the experimental groups, the vaccinations were carried out only once. Post-vaccination blood samples were collected at intervals of 1, 3, and 6 months. A total of 280 post-vaccination blood serum samples were evaluated with SNT for PPRV and BTV4 neutralizing antibodies. When the neutralizing antibody levels between the groups were compared, group 3 did not show any statistically significant difference insert ignore into journalissuearticles values(p>0.05); from group 1 and group 2. Based on the antibody response of simultaneous vaccination, it is shown that the simultaneous vaccination could be administered on the field, and could be labor and cost-effective.
Keywords : Aşı, BTV, PPRV, bağışıklık