Synthesis and Antibacterial Evaluation of Novel Benzimidazole, Benzothiazole, Benzofurane, and Naphtofurane Derivatives of Aminothiazoles

Authors : Zafer ŞAHİN, Büşra Işıl TOK, Erol AKGÜN, Erol AKGÜN, Ayşegül ÇAŞKURLU, Leyla YURTTAŞ, Barkın BERK, Şeref DEMİRAYAK

Pages : 231-240

View : 34 | Download : 12

Publication Date : 2022-08-01

Article Type : Research Paper

Abstract :The thiazole ring is the core of bioactive molecules that generate broad activity. These activities include anticonvulsant, antimicrobial, antituberculosis, antiviral, etc. In this work, starting from seconder/cyclic amines, new compounds containing thiazole and benzimidazole/benzothiazole/benzofurane/naphtofurane rings were synthesized, and their antimicrobial effects were evaluated. 9 compounds were synthesized by converting the seconder and cyclic amines to thiourea, and continued by thiazole ring closure. Ring closure was achieved by methylene-carbonyl condensation except conventional methods. Compound characterization was realized by FT-IR, 1H NMR and 13C NMR and HRMS. Compounds did not show significant activity on bacterial strains. Nine aminothiazole derivatives have been synthesized successfully. Compounds did not show important antibacterial activity and thus were evaluated as inactive.
Keywords : antibacterial, aminothiazole, benzothiazole, benzofurane, naphtofurane