The Effect of Troxerutin Consumption on the Symptoms of Morphine Withdrawal Syndrome in Male Mice

Authors : Ramin GHASEMİ SHAYAN, Nasrin HOSSEİNZAD MANİE

Pages : 183-200

Doi:10.55262/fabadeczacilik.1177914

View : 58 | Download : 44

Publication Date : 2023-08-01

Article Type : Research Paper

Abstract :Introduction: Chronic morphine use is associated with increased oxidative stress and inflammatory factors. Troxerutin is a natural bioflavonoid and has antioxidant and anti-inflammatory effects that could relieve morphine withdrawal syndrome. Aim: The effects of troxerutin on morphine dependence in mice Method: Troxerutin was prepared in three different doses insert ignore into journalissuearticles values(50, 100, and 200 mg/kg); via a normal saline solution. After examining the composition of troxerutin, the experiment was performed in five groups of 8 mice. One group received eight days of increasing doses insert ignore into journalissuearticles values(10, 20, 30, 40, 50, and 60 mg/kg); of morphine SC insert ignore into journalissuearticles values(subcutaneously); with normal saline insert ignore into journalissuearticles values(10 ml/kg); IP insert ignore into journalissuearticles values(Intraperitoneal);, and one group received only normal saline and the other three groups received three different doses of troxerutin solved in normal saline as the carrier of troxerutin along with morphine. On the ninth day, withdrawal symptoms were recorded after naloxone injection and blood samples were examined for antioxidant factors. Results: The total withdrawal score in the 50 mg/kg dose of the troxerutin group with morphine was significantly lower than the morphine-saline group insert ignore into journalissuearticles values(p 0.05);. Conclusion: Troxerutin reduces the symptoms of morphine withdrawal syndrome in a dose-dependent manner. The results of antioxidant tests declared that troxerutin would increase the level of TAC insert ignore into journalissuearticles values(Total Antioxidant Capacity); and decrease the level of MDA insert ignore into journalissuearticles values(Malondialdehyde); in the serum of mice possibly due to its antioxidant properties.
Keywords : morphine, troxerutin, withdrawal syndrome, dependence, MDA, TAC, mice