N-Alkylation of Some Imidazopyridines

Home Page
About
Submit A Journal
Submit A Conference
Submit Paper/Book
- Submit a Preprint
- Submit a Book
Contact

Fabad Eczacılık Bilimler Dergisi
Cilt: 50 Sayı: 1
N-Alkylation of Some Imidazopyridines

N-Alkylation of Some Imidazopyridines

Authors : Fatıma Doğanç, Ali Hakan Göker

Pages : 15-20

Doi:10.55262/fabadeczacilik.1577453

View : 27 | Download : 23

Publication Date : 2025-03-25

Article Type : Research Paper

Abstract :6-Bromo-2-(4-(4-fluorophenoxy)phenyl)-4H-imidazo[4,5-b]pyridine (I) and 2-[4-(4-fluorophenoxy)phenyl]-5H-imidazo[4,5-c]pyridine (III) were prepared by the reaction of 5-bromo-2,3-diaminopyridine and 3,4-diaminopyridine with sodyum metabisulfite adduct of 4-(4-fluorophenoxy)benzaldehyde (1), respectively. Alkylation of these compounds with 1-(chloromethyl)-4-methoxybenzene under basic conditions (K2CO3) in DMF) were formed as mainly N4 regioisomer (II) and N5 regioisomer (IV). Their regioisomeric structures were assigned with 2D-NOESY (Nuclear Overhauser Effect Spectroscopy) spectra.
Keywords : imidazopiridin, NOESY, regioizomer

ORIGINAL ARTICLE URL

VIEW PAPER (PDF)

* There may have been changes in the journal, article,conference, book, preprint etc. informations. Therefore, it would be appropriate to follow the information on the official page of the source. The information here is shared for informational purposes. IAD is not responsible for incorrect or missing information.