Formulation and Characterization of Microemulgel Containing Boesenbergia rotunda (L.) Mansf. Essential Oil as an Anti-Acne Agent

Authors : Sri Mulyaningsih, Alifathun Nur Winda Sari, Endang Darmawan, Nuri Efiana

Pages : 707-720

Doi:10.55262/fabadeczacilik.1716451

View : 57 | Download : 133

Publication Date : 2025-10-30

Article Type : Research Paper

Abstract :This study aimed to formulate and evaluate the physicochemical and antibacterial effects of a microemulgel of Boesenbergia rotunda essential oil (BREO) developed as an anti-acne agent. The BREO microemulgel was prepared using Tween 80 as a surfactant, PEG 400 as a co-surfactant, and Viscolam as a gelling agent. The microemulgel was evaluated for homogeneity, pH value, viscosity, spreadability, adhesion test and stability. The droplet size and zeta potential were measured using a Particle Size Analyzer (PSA). The antibacterial effects were tested using the diffusion method against Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis. BREO microemulsion using Tween 80-PEG 400 (25%:25%) obtained a clear and transparent microemulsion with transmittance percentage of 98.65 ± 0.40%. BREO microemulgels showed homogenous system, pH value of 5.95˗6.43, viscosity of 6411˗36569 cps, spreadability of 5.2˗5.5 cm, adhesion 3,62˗4,48 second, and no visible separation in the stability test. Each formulation exerted an antibacterial effect against bacteria-related acne, with 22.6˗24.6 mm inhibition zone diamaters. The formulation of F1B had a droplet size of 12 nm, and zeta potential -31.58 ± 0.30 mV. The BREO microemulgel formulation (F1B) met the physical properties, the stability, and the antibacterial activity to be developed as an anti-acne.
Keywords : akne vulgaris, mikroemülsiyon, parmak kökü, Propionibacterium acnes, yüzey aktif madde

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