A Potent Predictor of Poor COVID-19 Outcomes: Troponin/ Creatine Kinase-MB Ratio

Purpose: In this study, we aimed to derive significant implications by evaluating the predictive value of the troponin/CK-MB ratio, which has not been studied in previous research. Materials and Methods: We screened all COVID-19 patients admitted to the intensive care unit(ICU) between April 2020 and September 2022. All medical records, laboratory results, and in-hospital mortality were recorded. Results: We included 182 patients in this study. The overall correct classification rate of the proposed model was 83.0%. The Nagelkerke R² value explained 55.8% of the variance in mortality. The most predictive variable was the troponin/CK-MB ratio. An increase of 1 unit in the troponin/CK-MB ratio elevated the mortality risk by 108.90 times. A cut-off value for the troponin/CK-MB ratio, identified as the most predictive laboratory parameter, was determined to be 0.00745. Conclusion: The Troponin/CK-MB ratio has the potential to predict in-hospital mortality in COVID-19 patients. In the management of COVID-19 in the ICU, this ratio should be used to predict poor outcomes, assisting physicians in determining the optimal follow-up care for these patients