The Association Between Platelet Mass Index and Morning Blood Pressure Surge in Newly Diagnosed Hypertensive Patients

Authors : Alp Yıldırım, Muhammet Salih Ateş

Pages : 338-345

Doi:10.46332/aemj.1677106

View : 26 | Download : 74

Publication Date : 2025-12-22

Article Type : Research Paper

Abstract :Purpose: This study aimed to evaluate the relationship between Platelet Mass Index (PMI) and Morning Blood Pressure Surge (MBPS) in patients with newly diagnosed hypertension. Materials and Methods: A cross-sectional study was conducted between January and April 2025 at a tertiary cardiology outpatient clinic, including 158 hypertensive and 191 normotensive individuals. Blood pressure was monitored using Ambulatory Blood Pres-sure Monitoring (ABPM), and MBPS was calculated. PMI was derived by multiplying the platelet count by the mean platelet volume (MPV). The predictive ability of PMI for identifying elevated MBPS was assessed via receiver operating characteristic (ROC) curve analysis. Results: Systolic and diastolic blood pressure values across 24-hour, daytime, and nighttime measurements were significantly higher in the hypertensive group (all p 28.2 mmHg showed significantly higher platelet count, PMI, PLR, and neutrophil levels (p<0.001). PMI was strongly correlated with PLR (r=0.518, p<0.001), and inversely associated with nighttime systolic BP (r=–0.167, p=0.036). ROC analysis revealed that PMI had the highest discriminatory power with an AUC of 0.749, sensitivity of 67.1%, and specificity of 67.1%. Conclusion: PMI was significantly associated with exaggerated MBPS, suggesting that platelet activation may contribute to vascular stress and circadian BP dysregulation. PMI may represent a useful early biomarker for cardiovascular risk stratification in hyperten-sive patients.
Keywords : basınç değişkenliği, basınç paterni, sirkadiyen ritim, trombosit aktivasyonu, vasküler enflamasyon

ORIGINAL ARTICLE URL