The Effects of Acyl and Desacyl Forms of The Ghrelin Hormone on The Body

Authors : Emine ELİBOL, Yasemin AKDEVELİOĞLU

Pages : 18-27

View : 38 | Download : 14

Publication Date : 2020-04-30

Article Type : Review Paper

Abstract :Discovered as the endogenous ligand of the growth hormone secretagogue receptor, the ghrelin hormone is a small 28-amino acid peptide. This hormone is produced by certain tissues of the stomach, the brain, the liver, the kidneys, the pancreas, the pituitary gland, and adipose tissue. Major forms of ghrelin in plasma are acyl and desacyl ghrelin. While decacyl ghrelin was first thought to be an intermediate or degradation product of acyl ghrelin, today it has been found that desacyl ghrelin has metabolic effects on the body as a separate hormone. For this reason, this review was made to evaluate the effects of acyl and desacyl ghrelin on the body. Ghrelin causes a biological effect by binding to the growth hormone secretogogue receptors in the body. Only the acyl ghrelin hormone can bind to the growth hormone secretagogue receptor 1a. Des acyl cannot bind. As a result of studies, it has been determined that acyl ghrelin has an effect on appetite increase, growth hormone release, in addition to body weight and insulin resistance. Desacyl ghrelin has an effect on appetite decreas, body weight, as well as increase in insulin sensitivity. Moreover, it has been emphasized in recent years that desacyl ghrelin may be a strong inhibitor of the acyl ghrelin hormone. However, the effects of these two hormones in some patients are not fully understood. Therefore, studies investigating the effects of these hormones on different diseases should be conducted in the future.
Keywords : ghrelin, acyl ghrelin, desacyl ghrelin, disease