Desflurane Protects The Brain Against The Oxidant Activity of Acute Hyperglycemia in Diabetic Rats, Comparison with Sevoflurane

Authors : Alican KAYA, Mustafa ARSLAN, Elif BEŞKARDEŞ, Ömer KURTİPEK, Dilek KALAYCI, Alper Tunga DOGAN, Ayşe Hande ARPACI, Işın GÜNEŞ, Mustafa KAVUTCU

Pages : 34-41

Doi:10.59124/guhes.1223446

View : 21 | Download : 16

Publication Date : 2023-04-30

Article Type : Research Paper

Abstract :In this study, we investigated the effects of sevoflurane and desflurane administration on the oxidant and antioxidant system in the brain of acute hyperglycemia in diabetic rats. In the study, 30 male Wistar Albino rats were randomly divided into five groups. Diabetes was induced by administering a single dose of intraperitoneal streptozotocin insert ignore into journalissuearticles values(55 mg/kg); to rats except for the control group insert ignore into journalissuearticles values(C);. To create acute hyperglycemia in diabetic groups, which were hyperglycemia insert ignore into journalissuearticles values(DH);, desflurane insert ignore into journalissuearticles values(D);, and sevoflurane insert ignore into journalissuearticles values(S); groups, 2.5 g/kg glucose was administered intraperitoneally. After glucose administration, desflurane 6% and sevoflurane 2.3% mixed with 4 L/min oxygen were administered for 2 hours, by which minimal alveolar concentration for rats would be one. Afterward, the animals were sacrificed, and their brain tissues were prepared for biochemical analysis. Catalase insert ignore into journalissuearticles values(CAT);, glutathione-s-transferase insert ignore into journalissuearticles values(GST);, paraoxonase insert ignore into journalissuearticles values(PON); activities, and TBARS levels were measured to determine oxidant and antioxidant status. GST activity was significantly lower in group D than in group DH insert ignore into journalissuearticles values(p=0.001);. The PON activity was significantly lower in the D group compared with other groups insert ignore into journalissuearticles values(p<0.001);. In the S group, PON activity was significantly lower than in the diabetic control insert ignore into journalissuearticles values(DC); group and DH groups insert ignore into journalissuearticles values(p=0.022, p=0.020, respectively);. TBARS level was significantly lower in group D than in group DH insert ignore into journalissuearticles values(p=0.013);. As a result, desflurane decreases GST and PON activity and TBARS levels more than sevoflurane. In terms of lipid peroxidation, desflurane shows more protective properties than sevoflurane. Since our study is the first study in this field, it should be supported by other studies to be carried out.
Keywords : Antioxidant system, Brain, Desflurane, Diabetes Mellitus, Sevoflurane