Characteristics of Patients Administrated Thrombolytics in the Emergency Department

Authors : Ahmet Tolga ERASLAN, Fatih SELVİ, Cihan BEDEL, Muhammed BALTACIOĞLU, Günay YILDIZ

Pages : 51-55

Doi:10.54005/geneltip.1200029

View : 63 | Download : 14

Publication Date : 2023-02-28

Article Type : Research Paper

Abstract :Objective: Arterial and venous thromboembolism is one of the most prevalent diseases and related to ischemic stroke, pulmonary embolism, and myocardial infarction leading to mortality or morbidity. Fibrinolytic therapy is the most profound lifesaving therapy in these diseases. We aimed to evaluate the demographic features and post- tissue plasminogen activator insert ignore into journalissuearticles values(tPA); period of patients administered fibrinolytic in the emergency department insert ignore into journalissuearticles values(ED);. Materials and Methods: This retrospective study was conducted with patients instituted fibrinolytic therapy in the ED between January 2018 and July 2021. Age and gender of the patients, vital signs, laboratory tests, comorbidities, drugs used, lifesaving therapies secondary to the present pathology, tPA complications, mortality and similar presentations within the six months period were recorded to the study form. Results: A total of 277 patients were included into the study. Ischemic stroke was the most prevalent disease entailing the institution of tPA insert ignore into journalissuearticles values(n=252; 91%);. The study patients mostly used antihypertensives insert ignore into journalissuearticles values(n=155, 56%);, followed by anti-aggregants insert ignore into journalissuearticles values(n=101, 36.5%);. Intracranial hemorrhage insert ignore into journalissuearticles values(11.9%); was the most frequent complication secondary to tPA and the study patients had mostly undergone thrombectomy as a lifesaving therapy insert ignore into journalissuearticles values(n=34, 12.4%);. The univariate analysis revealed that antiaggregant usage insert ignore into journalissuearticles values(n=21, 53.8% vs n=80, 33.6%; p=0.01);, systolic blood pressure insert ignore into journalissuearticles values(160 mmHg, IQR: 138-190 vs 150 mmHg 130-169; p=0.02); and diastolic blood pressure insert ignore into journalissuearticles values(90 mmHg, IQR: 75-100 vs 83 mmHg, IQR: 72-94; p=0.03); differ between the patients with and without a post-tPA hemorrhage. Conclusion: According to the results of this study, ischemic stroke is the main pathology related to tPA administration in ED. Hypertension was the most seen comorbidity in study patients, mostly using anti-hypertensive and anti-aggregants. Intracranial hemorrhage was the most prevalent complication owing to tPA use, and systolic and diastolic blood pressures and anti-aggregant use pertain to post-tPA hemorrhages.
Keywords : fibrinolitik tedavi, inme, pulmoner emboli, intrakaniyal kanama

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