The protective effect of sildenafil on colon anastomosis in a rat model undergoing hypertermic intraperitoneal chemotherapy

Authors : Ahmet Başak, Mehmet Timuçin Aydın, Mehmet Mahir Fersahoğlu, İksan Taşdelen, Adnan Somay, Emre Teke, Erdem Durum, Kemal Memişoğlu

Pages : 374-381

Doi:10.54005/geneltip.1476892

View : 36 | Download : 30

Publication Date : 2025-04-30

Article Type : Research Paper

Abstract :Aim: The aim of this study was to investigate the effects of sildenafil on colonic anastomosis healing in rats treated with hyperthermic intraperitoneal chemotherapy. Method: In our study, 30 Wistar-albino rats were used. 30 rats were divided into 3 groups: the sildenafil, control and sham groups. Left colon anastomosis was performed on rats in all three groups.The HIPEC procedure was applied to sildenafil group and control group. During the postoperative period, sildenafil was given orally to the sildenafil group. On the 7th day, the anastomotic loop was excised, and bursting pressure, and adhesion were evaluated. Anastomotic loop was evaluated histopathologically. The results were compared statistically. Results: When the results were evaluated considering bursting pressure, and adhesion between the sildenafil group and control group, there was no difference. Considering adhesion, the sham group was superior to the other two groups. Histopathological examination reveals that the sham group was significantly superior to the other two groups in terms of anastomototic re-epitelization and muscle separation. There was a significant difference between the sildenafil group and the control group in terms of fibrosis and granulation. Conclusion: On colon anastomosis performed together with HIPEC application, histopathologically positive effects of sildenafil were observed. The burst pressure of colon anastomosis was not significantly different.
Keywords : Hipertermik intraperitoneal kemoterapi, Kolon anastomozu, Anastomoz iyileşmesi, Sildenafil