Investigation of Serum Brain-derived neurotrophic factor, Leptin and Ghrelin Levels in Missed Abortion: A Prospective Study

Authors : Fadime Ovalı, M. Gizem Keser, Sevcan Sarıkaya, Hüsamettin Vatansev
Pages : 421-425
Doi:10.54005/geneltip.1581914
View : 83 | Download : 56
Publication Date : 2025-06-30
Article Type : Research Paper
Abstract :Objective: The aim of this study is to investigate the relationship between serum leptin, ghrelin and Brain-derived neurotrophic factor (BDNF) in missed abortion. Method: 34 pregnant women diagnosed with missed abortion and 30 healthy pregnant women were included in this study. The women included in the study were between the ages of 19 and 42. Women in the first and second trimesters were selected in the control and study groups. Pregnant women who did not have a fetal heartbeat in the first 20th week of pregnancy were considered as missed abortion. The serum leptin, ghrelin and BDNF levels of these patients were compared with the serum leptin, ghrelin and BDNF levels of healthy pregnant women with the same gestational age between the two groups. Results: The median [IQR] serum level of Ghrelin was significantly higher in woman with missed abortion compared to the healthy controls (807.17 [IQR, 540.93 – 1385.61] vs. 267.14 [IQR, 211.63 – 360.65], U=961, p<.001, rrb=0.88 [95% CI: 0.80 to 0.93]). However, no significant differences were observed in serum level BDNF (270.28 [IQR, 196.91 – 639.57] vs. 265.31 [IQR, 171.46 – 422.85], U=394, p=.744, rrb=0.05 [95% CI: –0.25 to 0.35]) and Leptin (0.40 [IQR, 0.27 – 0.62] vs. 0.53 [IQR, 0.29 – 0.65], U=362, p=.847, rrb=0.03 [95% CI: –0.27 to 0.33]) between healthy controls and patients with missed abortion. Conclusion: In our study, we found that the serum ghrelin level was higher in patients with missed abortion compared to healthy pregnancies. It is important for future studies to further investigate the potential role of ghrelin in the etiopathogenesis of missed abortion.
Keywords : Missed abortion, BDNF, Ghrelin, Leptin

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