The Role of Antipsychotic Treatments in Neutrophil/Lymphocyte, Platelet/Lymphocyte, Monocyte/Lymphocyte, Monocyte/HDL Ratios and Systemic Immune Inflammatory Index Values for Patients with Schizophrenia

Authors : Memduha Aydın, Hacer Söylemez

Pages : 640-648

Doi:10.54005/geneltip.1645072

View : 102 | Download : 100

Publication Date : 2025-08-29

Article Type : Research Paper

Abstract :ABSTRACT Backround/Aims: Abnormal systemic inflammatory responses play a significant role in pathogenesis of schizophrenia. Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), monocyte-HDL ratio (MHR) and systemic immune inflammation index (SII) have recently been used as markers of inflammation. The aim of our study is to examine the relationship between NLR, PLR, MLR, MHR, and SII values of patients diagnosed with schizophrenia and antipsychotic treatments. Methods: One hundred ninety four individuals diagnosed with schizophrenia who were followed up in Psychotic Disorders Polyclinic of the Selcuk University Faculty of Medicine, were included in the study. Neutrophil, lymphocyte, platelet and monocyte counts, HDL values were obtained retrospectively from blood tests. NLR, PLR, MLR, MHR, and SII were calculated. Results: The mean age of patients was 44.38 ± 12.67 years. In total, 85 (43.8 %) patients were female. PLR, and SII were statistically significantly greater in females than in male group (p 0.05). However, a negative correlation was found between paliperidone long-acting injectable treatment duration and NLR and SII (PP-LAI and NLR, r: -0.26, p=0.026; PP-LAI and SII, r: -0.26, p=0.03). Conclusion: Our findings demonstrate a negative correlation between the duration paliperidone long-acting injectable treatment and NLR and SII. This suggests that a longer duration of paliperidone long-acting treatment may contribute to a reduction in inflammation. Also, differences were found between genders in PLR, MHR, and SII as a result. It is thought that understanding the gender-based differences and role of antipsychotic treatments on inflammatory markers may provide better understanding of schizophrenia pathogenesis and help to find better treatment options.
Keywords : Antipsikotik, inflamatuar yanıt, monosit/HDL oranı, monosit/lenfosit oranı, nötrofil/lenfosit oranı, trombosit/lenfosit oranı, sistemik immün inflamatuar indeks, şizofreni

ORIGINAL ARTICLE URL