Triglyceride-Glucose Index in Central Retinal Artery Occlusion: A Metabolic Risk Factor?

Authors : Ali Osman Gündoğan, Refik Oltulu, Selman Belviranlı, Ali Tezcan, Enver Mirza, Mehmet Adam, Mehmet Okka

Pages : 954-961

Doi:10.54005/geneltip.1683730

View : 133 | Download : 206

Publication Date : 2025-10-28

Article Type : Research Paper

Abstract :Aim: To evaluate the triglyceride glucose index (TGI) in patients with central retinal artery occlusion (CRAO) compared with controls and to determine its prognostic significance. Methods: A total of 54 CRAO patients and 54 healthy controls participated in this retrospective study. The TGI was calculated based on fasting plasma triglyceride and glucose levels and the results were evaluated between the different groups. To determine the optimal TGI threshold, ROC curve analysis was performed and its sensitivity and specificity were determined between the CRAO and control groups. Results: No statistically meaningful difference across the groups in terms of age and sex (p = 0.547 and p = 1.000, respectively). The TGI was identified as 8.46 [8.37, 8.59] in the control group and 8.86 [8.55, 9.10] in the CRAO group (p<0.001). The optimal ROC cutoff value for TGI distinguishing CRAO and control groups was determined as 8.68, with 63% sensitivity and 98% specificity (AUC: 0.865, p<0.001, 95% CI 0.800–0.931). Conclusion: Higher levels of TGI appear to be associated with the occurrence of CRAO. TGI may be a potential marker for CRAO. Because of the association of elevated TGI with increased metabolic and cardiovascular risk, patients with CRAO should be carefully evaluated.
Keywords : Santral Retinal Arter Tıkanıklığı, Trigliserid, Glukoz, Trigliserid-Glukoz İndeksi, Kan Lipid Profili

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