Yeni Schiff Bazlı Bileşiklerin Sentezi, Biyolojik Aktivite ve Moleküler Docking Çalışmaları

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Gümüşhane Üniversitesi Fen Bilimleri Dergisi
Volume:10 Issue:3
Yeni Schiff Bazlı Bileşiklerin Sentezi, Biyolojik Aktivite ve Moleküler Docking Çalışmaları

Yeni Schiff Bazlı Bileşiklerin Sentezi, Biyolojik Aktivite ve Moleküler Docking Çalışmaları

Authors : Dilek ÜNLÜER, Yasemin ÜNVER, Ersan BEKTAŞ, Şahin DİREKEL, Muhammet KARAMAN, Halide Sedef KARAMAN

Pages : 681-694

Doi:10.17714/gumusfenbil.679313

View : 46 | Download : 14

Publication Date : 2020-07-15

Article Type : Research Paper

Abstract :In this study, new thiophene Schiff bases with morpholine (1,2) were synthesized. The structures of the compounds were confirmed by 1 H-NMR, 13 C-NMR and IR spectrometry and t heir antioxidant, antibacterial, antileishmanial and enzyme activities were tested . The antioxidant activities observed from compounds 1 and 2 were remarkably high. According to the results obtained in our study, the compounds did not have antileishmanial activity (MIC >20000 µg/ml). It was determined that the synthesized compounds had different rates of antibacterial activity against nine different standard bacterial isolates. Enzyme inhibition effect of the compounds 1 and 2 was unimportant level and the compound exhibited low binding affinity against the enzyme in molecular docking studies. The compounds 1 and 2 formed many
Keywords : Antibacterial, Antileishmanial, Antioxidant, Enzym Activity, Morpholine, Schiff Base

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