Volumetric Analysis of the Cerebellum with the volBrain Method in Patients with Migraine

Authors : Özgür PALANCI, Zekeriya ALİOĞLU, Ali Faruk ÖZYAŞAR, Kübra ERTEN, Vildan ALTUNAYOGLU CAKMAK, İlker EYÜBOĞLU
Pages : 223-239
Doi:10.37989/gumussagbil.1228314
View : 49 | Download : 8
Publication Date : 2023-03-25
Article Type : Research Paper
Abstract :Migraine is a recurrent headache syndrome with a wide spectrum of symptoms. The diagnosis of migraine is mostly made retrospectively, taking into account the characteristics of the headache and other symptoms. It is not known enough how migraine headache starts and in which brain regions it occurs. It is known that changes in the excitability of brainstem nuclei affect endogenous pain mechanisms and unilateral involvement of trigeminovascular structures are effective mechanisms in migraine development. Understanding the role of the cerebellum in migraine disease is a fairly new topic in neuroscience. 19 Mıgraıne Patıents insert ignore into journalissuearticles values(MP); and 14 Healthy Controllers insert ignore into journalissuearticles values(HC); partıcıpated ın our study. For the volumetric analysis of the cerebellum, the ceres method of volbrain, which is an automatic brain volume calculation method, was used and the volumes of the cerebellum structures were obtained. SPSS 22.0 program was used for the analysis of the data and the level of significance was accepted as p<0.05. There is a significant increase in gray matter volumes of MP crus I, Crus II, lobus VIIB VIIIA, VIIIB and IX. When the cerebellum structures were examined according to the disease duration and attack frequency, a significant increase was found in the gray matter volumes of the cerebellum, crusII, lobule VIIB, and lobule VIIIA. These regions showed a positive correlation with attack frequency. As a result, posterior cerebellar structures show an activity that overlaps with the frequency of attacks and the duration of the disease. Volumetric or functional changes in the cerebellum indicate that it is effective in the pathophysiology of migraine pain.
Keywords : migren, serebellum, volBrain

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