Evaluation of Antioxidant Activity of 1, 2, 4-Triazole Derivatives With Morpholine Moiety

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Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi
Volume:42 Issue:2
Evaluation of Antioxidant Activity of 1, 2, 4-Triazole Derivatives With Morpholine Moiety

Evaluation of Antioxidant Activity of 1, 2, 4-Triazole Derivatives With Morpholine Moiety

Authors : Roman SHCHERBYNA, Yevhen PRUHLO, Maryna DUCHENKO, Mariia KULAGİNA, Victoriia KUDRİA, Vashchuk VALENTYNA

Pages : 73-82

Doi:10.52794/hujpharm.1033112

View : 65 | Download : 15

Publication Date : 2022-06-01

Article Type : Research Paper

Abstract :The aim of the work was to study the antioxidant activity of 4-R-3- (morpholinomethyl)-4H-1,2,4-triazole-5-thioles and their alkyl derivatives in vitro using the method of non-enzymatic initiation of lipid peroxidation. Among the 45 compounds studied, 8 showed varying degrees of AOA. The most pronounced AOA has 4-amino-3-(morpholinomethyl)-4H-1,2,4-triazole-5-thiol. It was found that in most cases the introduction in alkyl-derivatives of 4-R-3-(morpholinomethyl)-4H-1,2,4-triazole-5-thioles free amino group or phenyl substituent to the N4 atom of the 1,2,4-triazole nucleus, accompanied with increasing of AOA for test substances. In almost all cases, the presence on the N4 atom of 1,2,4-triazole nucleus methyl or ethyl groups has the opposite effect, even in comparison with control groups.
Keywords : 1 2 4 triazole, antioxidant activity, in vitro method

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