Galaxaura rugosa (J. Ellis & Solander) J.V. Lamouroux for Cosmeceutical Application: Antioxidant, Antibacterial, Tyrosinase and Elastase Inhibition Properties

Authors : Eldrin ARGUELLES

Pages : 218-227

Doi:10.52794/hujpharm.1064820

View : 28 | Download : 30

Publication Date : 2022-12-01

Article Type : Research Paper

Abstract :Red seaweeds are considered novel sources of natural products with diverse biological activities that can be harness for drug synthesis. The bioactive properties of red macroalga, Galaxaura rugosa were studied. Results showed that the macroalga contain a total phenolic content insert ignore into journalissuearticles values(TPC); of 12.11 ± 0.22 mg GAE/g. The antioxidant activity of G. rugosa exhibited potent ABTS+ radical scavenging activity insert ignore into journalissuearticles values(IC50 = 81.00 μg GAE/ml); and high copper reduction capacity insert ignore into journalissuearticles values(IC50 = 19.26 μg GAE/ml);. Assessment of tyrosinase and elastase inhibition properties of G. rugosa extract showed that the alga has effective inhibitory activity with IC50 of 88.00 μg GAE/ml and IC50 of 243.00 μg GAE/ml, respectively which are more efficient than kojic acid and tocopherol. The seaweed extract exhibited potent antibacterial activities against common bacterial skin pathogens like Staphylococcus aureus insert ignore into journalissuearticles values(Minimum Inhibitory Concentration insert ignore into journalissuearticles values(MIC); = 125 μg/ml);, Methicillin-resistant Staphylococcus aureus insert ignore into journalissuearticles values(MIC = 125 μg/ml);, and Staphylo- coccus epidermidis insert ignore into journalissuearticles values(MIC = 250 μg/ml);. This study is considered a pioneering investigation that shows the potential of G. rugosa for cosmeceutical application.
Keywords : biological activity, Cosmetic acpplication, Phenolic compounds, Seaweed, Skin Aging