Neuroprotective Effect of Farnesol Against Rotenone Induced Parkinson’s Disease in Drosophila Melanogaster

Authors : Jayaram SARAVANAN, Praveen Thaggikuppe KRİSHNAMURTHY

Pages : 15-21

Doi:10.52794/hujpharm.1080352

View : 50 | Download : 16

Publication Date : 2023-03-01

Article Type : Research Paper

Abstract :The current study aimed to investigate the neuroprotective effects of farnesol on rotenone-induced neurotoxicity in Drosophila melanogaster. Neurotoxicity was induced in Drosophila melanogaster by administering 500 μmol of rotenone and then the flies were administered either 300 μmol or 600 μmol of farnesol in the diet for the duration of the experiment. The study measured the effect of farnesol on longevity through a survival rate study, and locomotor function through a negative geotaxis assay. In addition, the study also estimated in vivo antioxidant parameters to determine the impact of farnesol on oxidative stress. The results showed that farnesol improved both longevity and locomotor function in the flies treated with 300 μmol or 600 μmol of test compound compared to control. The antioxidant studies also demonstrated that farnesol enhanced the catalase and superoxide dismutase activity and decreased lipid peroxidation. Based on these findings, it is concluded that farnesol might exhibit a significant neuroprotective effect against Parkinson’s disease.
Keywords : Farnesol, Drosophila melanogaster, negative geotaxis, survival rate, antioxidants

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