Novel treatment strategies for Triple-negative breast cancers: A comprehensive review

Authors : Jivika NAİK, Bhanudas KUCHEKAR, Ashwin KUCHEKAR, Rohini PUJARİ

Pages : 174-184

Doi:10.52794/hujpharm.1099683

View : 76 | Download : 91

Publication Date : 2023-06-01

Article Type : Review Paper

Abstract :Breast cancer has remained a serious health concern globally for women despite the healthcare advances which have enabled early diagnosis and treatment. Due to its metastatic ability and development of resistance to chemotherapies, triple-negative breast cancer is an extremely challenging subtype to treat. Targeted and optimized therapy is imperative as these tumors have higher recurrence rates than other types of breast cancers. This review is focused on the novel therapeutic strategies that have been proposed for the treatment of these aggressive cancers including alternative approaches like patient selection using biomarkers, metabolic reprogramming and development of smart drug delivery systems insert ignore into journalissuearticles values(SDDS); using targeted nanoparticles to treat the tumors as well as ensure prevention of recurrence. All of these approaches are aimed towards removing and treating the malignancies of triple-negative breast cancer insert ignore into journalissuearticles values(TNBC); and optimizing the therapies according to the patient cohorts. Further research is, however, necessary for the designing of an effective therapeutic regimen for patient sub-groups suffering from TNBC.
Keywords : Triple negative breast cancers, Metabolic reprogramming, Biomarkers, Nanoparticles, Smart drug delivery systems