Synthesis and Investigation of Cytotoxicity in Different Cell Lines of Novel Hydroxypyranones

Authors : Pelin Nur Üçkan, Gülşah Karakaya, Beyza Düzleyen, Canan Sevimli Gür, Mutlu Aytemir

Pages : 1-10

Doi:10.52794/hujpharm.1374319

View : 83 | Download : 58

Publication Date : 2024-07-01

Article Type : Research Paper

Abstract :Mannich bases synthesized from kojic acid have been determined in extensive studies conducted by our study group that they have a wide variety of biological activities. In this study, new anticancer-active compounds were synthesized from compounds with high anticancer activity. The compounds’ structures were identified through the utilization of spectroscopic methods and elemental analyses. The cytotoxicity screening of the compounds were done by MTT assay on different human cancer cell lines including MCF-7 and MDA-MB-231 (human breast cancer), SK-MEL (human melanoma), HT-29 (human colon adenocarcinoma), A549 (human lung carcinoma) cell line.Compound 1 bearing iodomethyl moiety, showed remarkable cytotoxicity with IC50 values in the range of 8.11 and 21.24 μg/mL. The IC50 value on Vero (African green monkey kidney epithelial) is over 100 μg/mL which means low cytotoxicity against healthy cells. Compared to this, SK-MEL cells have 12 times less IC50 value, with a therapeutic index over 12. The closest cytotoxic effectivity to KOJI MG84 which is previously reported as a cytotoxic agent, is observed on the SK-MEL cell line in compound 1, with 4 times less cytotoxic activity.
Keywords : kojik asit, Mannich bazları, sitotoksisite, antikanser

ORIGINAL ARTICLE URL