Plasma Free Amino Acid and Carnitine Levels in Pregnant Women with Hydatidiform Mole: A Case-Controlled Study

Authors : Hacer Uyanikoglu, İsmail Koyuncu, Sibel Sak, Mehmet Emin Tasduzen, Ataman Gönel, Muhammet Erdal Sak, Mert Ulaş Barut

Pages : 131-137

Doi:10.35440/hutfd.1381095

View : 35 | Download : 75

Publication Date : 2024-04-29

Article Type : Research Paper

Abstract :Background: To determine plasma free amino acid (FAA) and carnitine levels in pregnant women with hydatidiform mole (HM). Materials and Methods: Twenty-three pregnant women with HM, and 24 healthy pregnant wo-men as controls were enrolled in the study. FAA and carnitine concentrations were measured in plasma using liquid chromatography/tandem mass spectrometry (LC-MS). Results: The levels of alanine, arginine, and valine from the 14 amino acids examined were signif-icantly lower in the HM group than in the healthy group (p = 0.019, p = 0.009, and p = 0.03, respec-tively). In addition, several carnitines, C8DC, C16:1, and C18, of the 27 carnitines examined were significantly higher in the HM group than in the control group (p = 0.021, p = 0.03, and p = 0.021, respectively). Conclusions: This study demonstrated that a decrease in some plasma FAAs and an increase in some plasma carnitine levels might be effective in the pathogenesis of HM.
Keywords : karnitin, serbest amino asit, gebelik, hidatidiform mol