Serum Bilirubin Levels and Mortality Risk: Evaluation of Prognostic Use in a High-Risk Intensive Care Population

Abdullah Şen; Mahmut Yaman; Tahir Fırat Zadeoğlu; Ercan Gündüz; Murat Orak; Cahfer Güloğlu; Şilan Göger Ülgüt; Sema Belek; Berçem Tugay Günel; Mehmet Üstündağ

doi:10.35440/hutfd.1597292

Serum Bilirubin Levels and Mortality Risk: Evaluation of Prognostic Use in a High-Risk Intensive Care Population

Authors : Abdullah Şen, Mahmut Yaman, Tahir Fırat Zadeoğlu, Ercan Gündüz, Murat Orak, Cahfer Güloğlu, Şilan Göger Ülgüt, Sema Belek, Berçem Tugay Günel, Mehmet Üstündağ

Pages : 147-153

Doi:10.35440/hutfd.1597292

View : 30 | Download : 34

Publication Date : 2025-03-26

Article Type : Research Paper

Abstract :Background: Serum bilirubin serves as a crucial biomarker for liver function and may reflect the severity of systemic inflammatory responses in critically ill patients. This study aims to assess the prognostic significance of serum bilirubin levels in predicting mortality among high-risk patients admitted to the emergency intensive care unit (EICU). Materials and Methods: In this retrospective cohort study, an evaluation was conducted on high-risk patients admitted to the EICU between January 2020 and December 2022. The patients were grouped based on 28-day mortality outcomes. Serum bilirubin levels, along with other clinical and laboratory parameters, were recorded and examined using multivariable logistic regression and receiver operating characteristic (ROC) curve analysis. Results: The most common comorbidities were Chronic Obstructive Pulmonary Disease (COPD) (80.2%) and sepsis (67.2%). Multivariate analyses identified hypertension (OR=4.165, p=0.004), sepsis (OR=8.459, p<0.001), chronic kidney disease (OR=3.910, p=0.009), and total bilirubin levels (OR=1.605, p=0.036) as independent risk factors for mortality. ROC curve analysis demonstrated that a total biliru-bin cutoff value of 1.75 mg/dL provided 86.4% sensitivity and 60.0% specificity in predicting mortality. AUC was calculated to be 0.761, indicating that bilirubin levels possess significant power in distinguis-hing between surviving and died patients. Conclusions: Elevated serum bilirubin levels have been identified as an independent predictor of morta-lity in critically ill patients. This finding suggests that bilirubin levels can serve as a reliable indicator in prognostic evaluations within the EICU setting, thereby contributing to more effective management of the patients\\\' treatment process.
Keywords : bilirubin, mortalite, yoğun bakım ünitesi, prognostik belirteç, sepsis

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