Evaluation of Serum Paraoxonase Activity and Total Oxidant and Antioxidant Capacity in Infants of Diabetic Mothers

Authors : Süleyman Geter, Mehmet Kılıç, Alpay Çakmak

Pages : 692-697

Doi:10.35440/hutfd.1704098

View : 49 | Download : 98

Publication Date : 2025-12-25

Article Type : Research Paper

Abstract :Background: This study aims to evaluate the paraoxonase (PON) activity, total oxidant (TOS) levels, and antioxidant capacities (TAS) in infants of diabetic mothers (IDM), to assess the risk of atherosclerosis formation. Materials and Methods: A total of 58 infants born to mothers with pregestational or gestational diabetes who were followed up prospectively between 01.03.2012 and 25.09.2012 and were within the first 3 postnatal days were included in the study. Healthy infants without maternal risk factors were selected as the control group. The levels of PON, TOS, and TAS were compared between the groups. Results: PON1 activity, TOS levels, and oxidative stress index were found to be significantly higher in IDM compared to the control group (p<0.01, p<0.01, p<0.01, respectively). However, no significant difference was found in serum TAS levels between the IDM and the control group (p=0.446). Conclusions: Achieving glycemic control in diabetic mothers through intrauterine programming may reduce oxidative stress and the risk of atherosclerosis development by reducing the exposure of infants to hyperglycemia.
Keywords : Diyabetik anne bebeği, Serum paraoksonaz aktivitesi, Oksidan-antioksidan sistem

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