Determination of the Presence, Virulence Factors, and Antimicrobial Susceptibility of Salmonella spp. in Neonatal Calf Diarrhoea in the Aegean Region

Authors : Çağatay Nuhay, Deha Ali Deniz, Volkan Özavcı

Pages : 122-129

Doi:10.31196/huvfd.1725182

View : 81 | Download : 126

Publication Date : 2025-12-24

Article Type : Research Paper

Abstract :The objective of this study was to investigate the prevalence, virulence gene profiles, and antimicrobial susceptibility of Salmonella spp. Isolates from neonatal calves with diarrhoea in the Aegean region of Türkiye. A total of 185 faecal samples from affected calves were collected and examined. Salmonella spp. were isolated from 4.3% of the samples. Molecular analysis revealed the presence of virulence genes invA, stn, mgtC, and misL in all isolates, which are associated with invasion, toxin production, intracellular survival, and host cell adhesion. Antimicrobial susceptibility testing revealed that all isolates were fully susceptible to cefepime, levofloxacin, ciprofloxacin, cefotaxime, amoxicillin/clavulanic acid, and colistin sulphate, while varying degrees of resistance to tetracycline group antibiotics were observed. These results suggest that, despite the low prevalence of Salmonella, the isolated strains demonstrated significant virulence potential and emerging resistance patterns. To prevent the spread of resistant strains and improve the management of neonatal calf diarrhoea, it is essential to implement continuous monitoring of antimicrobial susceptibility and establish appropriate therapeutic strategies.
Keywords : Antibiotic Resistance, Neonatal Calf Diarrhea, PCR, Salmonella spp., Virulence

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