Comparison Of The Effects Of Different Anesthesia Protocols On Intraocular Pressure In Rats

Authors : Muhammed Kaan Yönez, Nevzat Emre Aslan, Umut Alpman, Gültekin Atalan

Pages : 137-142

Doi:10.31196/huvfd.1784634

View : 84 | Download : 163

Publication Date : 2025-12-24

Article Type : Research Paper

Abstract :Intraocular pressure (IOP) provides biomechanical support to the internal tissues as well as protecting the optical properties of the eye. Deviations from baseline values cause vision problems depending on the magnitude, direction, and duration of IOP changes. In the study, rats determined to be healthy were first randomly divided into 4 groups. In all groups, the right and left intraocular pressures of the rats were measured and recorded with a tonometer at 0 minutes. After the administration of the general anesthetic agent, the right and left intraocular pressures were measured and recorded at 20, 30, 60, 90, and 120 minutes. In the intra-group comparisons, it was observed that IOP values decreased over time in all anesthesia protocols applied. No significant difference was observed between the groups in the comparison of right and left eye IOP values of all groups between 0-30 min and 90-120 min (p>0.05). At 60 min, statistically significant differences were found between groups in both right and left eye IOP values (p<0.05). In conclusion, a decrease in IOP values in both the right and left eyes was observed in all anesthetic protocols applied. Based on the data obtained, it was concluded that the combination of xylazine-medetomidine-propofol-ketamine anesthesia can be used safely in rats without causing an adverse effect on IOP.
Keywords : Anesthesia, intraocular pressure, ketamine, medetomidine, propofol, xylazine

ORIGINAL ARTICLE URL