One-Pot Synthesis of Substituted Phthalazine-5,10-dione Derivatives in the Presence of Triflate Catalyst

Authors : Kadir TURHAN

Pages : 468-478

Doi:10.21597/jist.433331

View : 60 | Download : 10

Publication Date : 2019-03-01

Article Type : Research Paper

Abstract :In this study, substituted 1 H -pyrazolo[1,2- b ]phthalazine-5,10-diones which are considered that may possess biological activity have been obtained via one-pot multi-component cyclocondensation reaction of phthalhydrazide, aromatic aldehydes and malononitrile catalyzed in the presence of Cu(OTf) 2 in very good yields and short times. The structures of all these synthesized compounds (4a-f) have been determined and characterized by infrared, nuclear magnetic resonance, mass spectral data, and elemental analysis.
Keywords : triflate, one pot, Phthalazinedione, multicomponent, green chemistry

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