Identification of Free Radicals Formed in Gamma-Irradiated Chlorpropamide and Procainamide Hydrochloride Pharmaceutical Raw Materials by EPR Spectroscopy

Authors : Kerem Sütçü, Yunus Emre Osmanoğlu

Pages : 2616-2621

Doi:10.21597/jist.1302560

View : 52 | Download : 71

Publication Date : 2023-12-01

Article Type : Research Paper

Abstract :In this study, it was aimed to determine the structural properties of free radicals formed by gamma irradiation in chlorpropamide and procainamide hydrochloride drug raw materials, which are widely used in medicine, by using electron paramagnetic resonance spectroscopy. As a result of gamma irradiation, it was determined that two different radicals were formed in both chlorpropamide and procainamide hydrochloride samples. It was suggested that –NĊH-, -NCH2ĊH2- and –NĊH-, -NĊHCH2- radicals were formed in chlorpropamide and procainamide hydrochloride samples, respectively. The simulated spectra closest to the experimental spectra recorded at room temperature of the samples studied in powder form were obtained using simulation software. The contributions of the proposed radicals to the experimental spectra were calculated. The g values of the obtained radicals and the hyperfine structure constants of the unpaired electrons were calculated.
Keywords : Elektron paramanyetik rezonans, Gama ışınlaması, İlaç hammaddesi