Development and Analysis of Metabolic Syndrome Feeds for Laboratory Animals (Rats and Mice)

Authors : Tayfun İde, Aşkın Nur Derinöz Erdoğan, Naim Deniz Ayaz

Pages : 15-23

View : 42 | Download : 93

Publication Date : 2024-04-30

Article Type : Research Paper

Abstract :Feeding a high-fat diet causes obesity and metabolic disorders in rodents that resemble human metabolic syndrome. The aim of this study was the preparation and characterization of casein-based high-fat feeds to induce metabolic syndrome in laboratory animals (rats and mice). In this study, three different concentrations of high-fat feeds (24, 35 and 45%), which are stable, non-pollinating and shedding, were developed in pellet form. The parameters used in the characterization of feeds were established within the specific features required for these feeds to achieve their usage goals. To determine various components and properties of prepared feeds; In addition to physical, chemical and microbiological analyses, in-vivo nutritional tests were carried out by comparing them with imported commercial products developed for the same purposes. The results showed that the products obtained were in accordance with the production targets and were like the analysis values of the imported feeds compared. In conclusion, the study revealed that locally developed casein-based high-fat pellet feeds can be used reliably in studies of various companies and research centers to create obesity and metabolic disorders in experimental animals.
Keywords : Yüksek yağlı yem, obezite, metabolik sendromlu diyetler, laboratuvar hayvanları