Non alkolik steatohepatitli hastalarda antinükleer antikor prevalansı ve önemi

Authors : Selim AYDEMİR, İshak Özel TEKİN, Hüseyin ENGİN, Erdem KOÇAK, Ayşe Semra DEMİR, Yücel ÜSTÜNDAĞ

Pages : 158-161

View : 23 | Download : 14

Publication Date : 2005-12-01

Article Type : Research Paper

Abstract :Background/aim: Antinuclear antibodies (ANA) have been shown in patients with non-alcoholic steatohepatitis (NASH), although their prevalence and significance are uncertain. The aim of this study was to evaluate the prevalence and to determine whether their presence has any biochemical significance. Materials and methods: Laboratory data from 55 patients with a histologic diagnosis of NASH were reviewed retrospectively. ANA were detected by indirect immunofluorescence on HEp2 cells and monkey liver tissue, with a dilutional titer of 1:100 and above considered positive. Results: The mean age of the study population was 43.1±10.4 years. Thirty-eight percent (21/55) of subjects were women. The mean body mass index (BMI) was 29.9±3.1 kg/m2. Twenty-five percent (14/55) of patients with NASH had positive ANA titers. Age, gender, BMI, ALT, AST, GGT, ALP, albumin, total cholesterol, triglycerides and ferritin levels were similar between ANA-positive and negative cases (p>0.05). ANA-positive patients were associated with higher levels of globulin (p
Keywords : Non alkolik steatohepatit, anti nükleer antikor