Investigation of the Effect of Granulocyte Colony-Stimulating Factor on Endometrial Thickness in the Wistar Albino Rat

Authors : Sadun Sucu, Ülkü Özmen

Pages : 484-492

Doi:10.38136/jgon.1674394

View : 26 | Download : 74

Publication Date : 2026-01-03

Article Type : Research Paper

Abstract :Abstract Problem: A thin endometrium is a difficult situation for infertile patients and the doctors who treat them. In our study, we wanted to investigate the efficacy of G-CSF, which can be used for the treatment of infertile couples with thin endometrium, by examining the effect of GCSF on the endometrium in rats. Method of Study: In our study, which we used as an animal model, we divided 50 rats into five groups and investigated the effect of G-CSF on thin, rat endometriums obtained using alcohol. Endometrial and uterine thickness were performed semi-quantitatively by an impartial pathologist. At the end of the study, the rats\\\' hemoglobin levels and weight were measured. Results: When the pathological samples were examined, it was found that G-CSF increased the thickness of the endometrial surface epithelium at the dose and duration administered, but had no effect on the thickness of the uterus and endometrium. Weight and hemoglobin levels were lower in the groups of rats exposed to the surgical procedure than in the control group. Conclusions: The effect of G-CSF on the endometrium is evaluated differently in various studies in the literature. The main reason for this is that studies on the thin endometrium are not physiopathologically standardized. In our study, we found that G-CSF increased the thickness of the endometrial surface epithelium. We believe that this promotes embryo implantation.
Keywords : infertilite, G-CSF, endometrium, sıçan

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