THE ASSOCIATION BETWEEN APRI, FIB-4 and FIB-5 SCORES, HIPEREMESIS GRAVIDARUM and DISEASE SEVERITY

Authors : Mehmet Efe Namli, Hande Kurt Güven
Pages : 455-461
Doi:10.38136/jgon.1766750
View : 45 | Download : 84
Publication Date : 2026-01-03
Article Type : Research Paper
Abstract :Aim: The aim of this study is to determine the association between hyperemesis gravidarum and the non-invasive liver fibrosis indices APRI, FIB-4, and FIB-5, in order to evaluate whether these indices could be used as predictive markers for the presence and severity of the disease. Materials and Methods: This cross-sectional retrospective study was conducted on 100 pregnant women diagnosed with HG, and 100 gestational age- and age-matched healthy pregnant women, at a tertiary hospital between December 2022 and December 2024. Demographic data, laboratory parameters, and PUQE scores were collected from the hospital database and APRI, FIB-4, and FIB-5 scores were calculated using standard formulas. Comparisons were made between the two groups, and any correlations between disease severity and these indices were determined. Logistic regression and ROC analysis were performed to identify the predictive value of these scores. Results: Mean APRI and FIB-4 scores were significantly higher in the HG group compared to controls, while FIB-5 scores were significantly lower (p<0.001). Increased disease severity correlated with rising APRI and FIB-4 and decreasing FIB-5 scores. Logistic regression revealed APRI and FIB-4 as independent predictors of both disease presence and severity (OR for APRI = 19.267 and 5.945; OR for FIB-4 = 3.218 and 4.502, respectively). ROC analysis identified optimal cut-off values for APRI (≥0.25) and FIB-4 (≥0.64) with high sensitivity and specificity in identifying HG. Conclusion: APRI and FIB-4 are significantly elevated in patients with HG and strongly correlate with disease severity. These simple, cost-effective, and non-invasive indices have the potential of being valuable tools in the early identification and risk stratification of HG, as well as determining the severity of the disease.
Keywords : hiperemezis gravidarum, APRI, FIB-4, FIB-5, karaciğer fibrozisi, invaziv olmayan biomarker

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