Behçet’s Disease and Pregnancy: Increased Risk of Preterm Birth and the Role of Mucocutaneous Activity

Authors : Murad Gezer, Özlem Pehlivan, Halise Hande Gezer, Özlem Aldemir Bukağıkıran, Mucize Eriç Özdemir

Pages : 420-426

Doi:10.38136/jgon.1780296

View : 32 | Download : 117

Publication Date : 2026-01-03

Article Type : Research Paper

Abstract :Objective: This study aimed to evaluate and compare the pregnancy outcomes of women with Behçet’s disease (BD) before and after the diagnosis. Methods: This retrospective cross-sectional study included 100 pregnancies from 30 women diagnosed with BD. Clinical characteristics, treatments, and obstetric outcomes were assessed. Pregnancy outcomes were compared between those occurring before and after BD diagnosis. Additionally, factors associated with live birth without adverse outcomes were analyzed. Results: Of the 100 pregnancies, 52 occurred before and 48 after the diagnosis of BD. The post-diagnosis group had significantly lower gestational age at delivery (p < 0.001), a higher rate of preterm birth (25.7% vs. 7.3%, p = 0.03), and increased cesarean delivery rates (54.3% vs. 19.5%, p = 0.002). No significant differences were observed in miscarriage, NICU admission, neonatal jaundice, anomaly, or perinatal mortality. In multivariate analysis, erythema nodosum was the only independent predictor of adverse pregnancy outcomes (OR 5.66, 95% CI: 1.07–29.92, p = 0.041). Conclusion: Pregnancies following the diagnosis of BD are associated with increased risks of preterm birth and cesarean delivery. Patients with erythema nodosum was independently associated with adverse obstetric outcomes. Close monitoring remains essential to optimize maternal and fetal health in patients with BD.
Keywords : Behçet, Gebelik, Preterm, Sezaryen, Kolşisin

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