The Effect of Early Neonatal Sepsis on Bronchopulmonary Dysplasia in Very Low Birth Weight Infants

Authors : Buse OZER BEKMEZ, Mehmet BÜYÜKTİRYAKİ

Pages : 1718-1722

Doi:10.38136/jgon.1233805

View : 22 | Download : 84

Publication Date : 2023-07-03

Article Type : Research Paper

Abstract :Objective Bronchopulmonary dysplasia insert ignore into journalissuearticles values(BPD); remains critical morbidity in very low birth weight insert ignore into journalissuearticles values(VLBW); infants. The etiology is multifactorial, and inflammation plays an essential role in the pathogenesis. We aimed to investigate the effect of early neonatal sepsis insert ignore into journalissuearticles values(ENS); on BPD and other preterm morbidities in VLBW infants. Materials and Methods Preterm infants of <30 weeks of gestation and birth weight <1500 g were incorporated in this retrospective study. We reviewed the records of infants who admitted to the neonatal intensive care unit between 2013 and 2016. Those with ENS diagnosis were assigned to the study group, while the remaining constituted the control group. Babies with major congenital anomalies, perinatal asphyxia, and missing data were excluded from the study. Results This study included a total of 390 infants. The gestational ages and birth weights were statistically similar in the groups. Moderate-to-severe BPD insert ignore into journalissuearticles values(p=0.04); and requirement for invasive ventilation were more frequent, but survival without BPD at 36 weeks corrected insert ignore into journalissuearticles values(p=0.03); was lower in the ENS group. While laser treatment requiring ROP was significantly more common in the ENS group insert ignore into journalissuearticles values(p=0.03);, there was no difference between the groups regarding other preterm morbidities. In the multivariate logistic regression analysis, ENS was not noted an independent risk factor for moderate/severe BPD. Conclusion Although the rate of moderate/severe BPD is higher in VLBW infants with ENS, it was not an independent risk factor for BPD or other preterm morbidities.
Keywords : prematürite, erken sepsis, bronkopulmoner displazi