Assessment of the Fibrinogen-to-Albumin Ratio in Predicting the Severity of Hyperemesis Gravidarum

Authors : Zahid Ağaoğlu, Atakan Tanacan, Betül Akgün Aktaş, Esra Karatas, Gülcan Okutucu, Hakkı Şerbetçi, Özgür Kara, Dilek Sahin

Pages : 309-315

Doi:10.38136/jgon.1457845

View : 73 | Download : 95

Publication Date : 2024-12-28

Article Type : Research Paper

Abstract :Objective: To investigate whether the fibrinogen-to-albumin ratio (FAR.) could predict the severity of disease in hyperemesis gravidarum (HG). Materials and Methods: This study was designed prospectively at a single tertiary center and included a total of 283 patients with HG. The patients were divided into the following groups based on the severity of the disease evaluated using the Pregnancy-Unique Quantification of Emesis scoring system: mild HG (n=144) (score6), moderate HG (n=80) (score: 7-12), and severe HG (n=59) (score13). FAR was calculated by dividing fibrinogen by albumin. Results: There was a significant difference between the HG groups in terms of the gestational week at disease onset (p<0.001). In the severe HG group, the rate of weight loss due to nausea and vomiting and the rate of hospitalization were significantly higher (p<0.001 for both). The FAR value was 0.075 ± 0.015, 0.089 ± 0.019, 0.12 ± 0.023 for the mild, moderate and severe HEG groups, respectively. The FAR value increased as the disease severity increased and was found to be significantly higher in the severe HG group (p<0.001). Using the receiver operating characteristic analysis, the optimal cut-off value of FAR in predicting severe HG was determined to be 0.09 with 88% sensitivity and 85% specificity (area under the curve=0.931; p<0.001). Conclusion: As the severity of HG increased, the FAR value increased and predicted disease severity with high sensitivity. This novel marker has the potential to reduce the adverse maternal and perinatal consequences of HG by facilitating the detection of severe disease, and it may also offer a pathway for promptly initiating individual treatment for severe HG.
Keywords : albumin, fibrinojen, fibrinojen/albumin oranı, hiperemezis gravidarum