Is the use of first-trimester systemic inflammation markers predictive in fetal growth restriction?

Authors : Zahid Ağaoğlu, Atakan Tanacan, Ramazan Denizli, Bedri Sakcak, Nihat Farisoğulları, Murat Haksever, Özgür Kara, Dilek Sahin

Pages : 7-11

Doi:10.38136/jgon.1578631

View : 67 | Download : 46

Publication Date : 2025-03-22

Article Type : Research Paper

Abstract :Aim: To predict fetal growth restriction (FGR) and its effect on prognosis according to changes in systemic inflammation indexes, such as the neutrophil-to-lymphocyte ratio (NLR), the systemic immune-inflammation index (SII), and the systemic inflammation response index (SIRI). Materials and Methods: The study group consisted of 200 women with singleton pregnancies diagnosed with FGR, and the control group comprised 280 obstetrically and demographically matched healthy pregnant women. The NLR, SII, and SIRI were compared between the groups according to the first-trimester complete blood count results. Results: When the groups were compared in terms of systemic inflammation indexes, the NLR, SII, and SIRI were found to be statistically lower in the FGR group (p<0.001, p=0.01, and p=0.03, respectively). Conclusion: We found that the NLR, SII, and SIRI were lower in pregnant women with FGR compared to the control group, according to the first-trimester complete blood count analysis.
Keywords : fetal büyüme kısıtlılığı, nötrofil-lenfosit oranı, sistemik immün-inflamasyon indeksi, sistemik inflamasyon yanıt indeksi